Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of motor function. Although the cause of Parkinson's is unknown, advances have been made in understanding its pathogenesis. Symptoms of Parkinson's disease result from cell death in the sustantia nigra midbrain region resulting in the formation of Lewy bodies. Defects in multiple cell pathways may initiate a cascade of neuronal cell death. These include abnormal protein accumulation, defective protein degradation, mitochondrial dysfunction, oxidative stress, inflammation, and dysregulated kinase signaling. The genes represented in the Parkinson's disease PCR Primer Library include members of these pathways as well as several genes identified as mutated in Parkinson's patients and genes that have been shown to be overexpressed in this disese.

A ready-to-use Human Parkinson's Disease PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against Parkinson's disease related genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



Gene List:

APAF1 apoptotic peptidase activating factor 1

ATG5 autophagy related 5

ATG7 autophagy related 7

ATP13A2 ATPase type 13A2

ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2

ATXN2 ataxin 2

CASP2 caspase 2, apoptosis-related cysteine peptidase

CASP3 caspase 3, apoptosis-related cysteine peptidase

CASP6 caspase 6, apoptosis-related cysteine peptidase

CASP7 caspase 7, apoptosis-related cysteine peptidase

CASP9 caspase 9, apoptosis-related cysteine peptidase

CCNE1 cyclin E1

CCNE2 cyclin E2

CYCS cytochrome c, somatic

DCTN1 dynactin 1

DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)

DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13

DRD2 Dopamine receptor D2

EIF4G1 eukaryotic translation initiation factor 4 gamma, 1

ERS Data not found

FBXO2 F-box protein 2

FBXO7 F-box protein 7

FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

GAK cyclin G associated kinase

GBA glucosidase, beta, acid

GLA galactosidase, alpha

GPNMB glycoprotein (transmembrane) nmb

GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)

GRN granulin

GSK3A glycogen synthase kinase 3 alpha

HTRA2 HtrA serine peptidase 2

LAMP2 lysosomal-associated membrane protein 2

LAMP3 lysosomal-associated membrane protein 3

LINGO1 leucine rich repeat and Ig domain containing 1

LINGO2 leucine rich repeat and Ig domain containing 2

LRRK1 Leucine-rich repeat kinase 1

LRRK2 Leucine-rich repeat kinase 2

M6PR mannose-6-phosphate receptor (cation dependent)

MAPK11 mitogen-activated protein kinase 11

MAPK12 mitogen-activated protein kinase 12

MAPK13 mitogen-activated protein kinase 13

MAPK14 mitogen-activated protein kinase 14

MAPT microtubule-associated protein tau

MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)

MEF2D myocyte enhancer factor 2D

MFN1 mitofusin 1

MFN2 mitofusin 2

NPC1 Niemann-Pick disease, type C1

NPC2 Niemann-Pick disease, type C2

NR4A2 nuclear receptor subfamily 4, group A, member 2

NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1

PARK16 Parkinson disease 16 (susceptibility)

PARK2 parkin RBR E3 ubiquitin protein ligase

PARK7 Parkinson disease (autosomal recessive, early onset) 7

PINK1 PTEN induced putative kinase 1

PM20D1 peptidase M20 domain containing 1

POLG polymerase (DNA directed), gamma

PRKN Parkin

RAB29 RAB29, member RAS oncogene family

SCARB2 scavenger receptor class B, member 2

SEPT5 septin 5

SLC41A1 solute carrier family 41 (magnesium transporter), member 1

SLC45A3 solute carrier family 45, member 3

SLC6A3 Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal

SNCA synuclein, alpha (non A4 component of amyloid precursor)

SNCAIP synuclein, alpha interacting protein

SQSTM1 sequestosome 1

SREBF1 sterol regulatory element binding transcription factor 1

SREBF2 sterol regulatory element binding transcription factor 2

SYNJ1 synaptojanin 1

SYT11 synaptotagmin XI

TFEB transcription factor EB

TH tyrosine hydroxylase

TMEM175 transmembrane protein 175

UBA1 Ubiquitin-like modifier activating enzyme 1

UBA7 ubiquitin-like modifier activating enzyme 7

UBB ubiquitin B

UBE2G1 ubiquitin-conjugating enzyme E2G 1

UBE2G2 ubiquitin-conjugating enzyme E2G 2

UBE2J1 ubiquitin-conjugating enzyme E2, J1

UBE2J2 ubiquitin-conjugating enzyme E2, J2

UBE2L3 ubiquitin-conjugating enzyme E2L 3

UBE2L6 Ubiquitin-conjugating enzyme E2L 6

UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

VCP valosin containing protein

VPS35 vacuolar protein sorting 35

WASH1 WAS protein family homolog 1

ACTB Actin, beta

B2M Beta-2-microglobulin

GAPDH Glyceraldehyde-3-phosphate dehydrogenase

GUSB Glucuronidase, beta

HPRT1 Hypoxanthine phosphoribosyltransferase 1

Pgk1 Phosphoglycerate kinase 1

PPIA Peptidylprolyl isomerase A

RPL13A Ribosomal protein L13a
$495.00
HPKD-I