Glial cell line-derived neurotrophic factor (GDNF) is a growth factor that promotes the survival and differentiation of neurons, particularly dopaminergic and motor neurons. GDNF family ligands (GDNF, neurturin, artemin and persephin) bind GPI anchored GFR-alpha coreceptors, and the complex activates the RET receptor tyrosine kinase. RET signaling activates the RAS-MAPK, PI3K-AKT, PLC-gamma and SRC pathways. GDNF signaling is essential for kidney and enteric nervous system development and spermatogenesis and is studied as a therapeutic approach for Parkinson's disease.
A ready-to-use Human GDNF Signaling PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against GDNF signaling genes and 8 housekeeping gene primer sets. Provided in a 96-well microplate (20 ul - 10 uM) Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction) Just add cDNA template and SYBR green master mix GENE LIST: ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT2 v-akt murine thymoma viral oncogene homolog 2 AKT3 v-akt murine thymoma viral oncogene homolog 3 ARTN artemin BAD BCL2-associated agonist of cell death BAX BCL2-associated X protein BCL2 B-cell CLL/lymphoma 2 CDC25A cell division cycle 25A CDK2 cyclin-dependent kinase 2 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) CREB1 cAMP responsive element binding protein 1 DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) FLT1 fms-related tyrosine kinase 1 FOS FBJ murine osteosarcoma viral oncogene homolog FRS2 fibroblast growth factor receptor substrate 2 FYN FYN proto-oncogene, Src family tyrosine kinase GAB1 GRB2-associated binding protein 1 GAB2 GRB2-associated binding protein 2 GAS1 growth arrest-specific 1 GDNF glial cell derived neurotrophic factor GFRA1 GDNF family receptor alpha 1 GFRA2 GDNF family receptor alpha 2 GFRA3 GDNF family receptor alpha 3 GFRA4 GDNF family receptor alpha 4 GRB2 growth factor receptor-bound protein 2 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 HES1 hes family bHLH transcription factor 1 HEY1 hes-related family bHLH transcription factor with YRPW motif 1 HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HRAS Harvey rat sarcoma viral oncogene homolog IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma IL1B interleukin 1, beta IL6 interleukin 6 IL8 interleukin 8 IRS1 insulin receptor substrate 1 IRS2 insulin receptor substrate 2 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) JAG1 Jagged 1 JAK1 Janus kinase 1 JAK2 Janus kinase 2 JAK3 Janus kinase 3 JUN jun proto-oncogene KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog MAP2K1 mitogen-activated protein kinase kinase 1 MAP2K2 mitogen-activated protein kinase kinase 2 MAP2K7 mitogen-activated protein kinase kinase 7 MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase MAPK1 mitogen-activated protein kinase 1 MAPK10 mitogen-activated protein kinase 10 MAPK3 mitogen-activated protein kinase 3 MAPK8 mitogen-activated protein kinase 8 MAPK9 mitogen-activated protein kinase 9 MET MET proto-oncogene, receptor tyrosine kinase MMP2 matrix metallopeptidase 2 MMP7 matrix metallopeptidase 7 MMP9 matrix metallopeptidase 9 MYC V-Myc Myelocytomatosis Viral Oncogene Homolog NCAM1 neural cell adhesion molecule 1 NCK1 NCK adaptor protein 1 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 NOTCH1 notch 1 NRTN neurturin PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 PDLIM7 PDZ and LIM domain 7 (enigma) PLCG1 phospholipase C, gamma 1 PRKCA protein kinase C, alpha PROM1 prominin 1 PSPN persephin PTEN phosphatase and tensin homolog PTK2 protein tyrosine kinase 2 RAF1 Raf-1 proto-oncogene, serine/threonine kinase RET ret proto-oncogene RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 SOS1 son of sevenless homolog 1 (Drosophila) SRC SRC proto-oncogene, non-receptor tyrosine kinase TERT telomerase reverse transcriptase TFF1 trefoil factor 1 TNF tumor necrosis factor TP53 tumor protein p53 TWIST1 twist family bHLH transcription factor 1 VEGFA vascular endothelial growth factor A ACTB Actin, beta B2M Beta-2-microglobulin GAPDH Glyceraldehyde-3-phosphate dehydrogenase GUSB Glucuronidase, beta HPRT1 Hypoxanthine phosphoribosyltransferase 1 PGK1 Phosphoglycerate kinase 1 PPIA Peptidylprolyl isomerase A RPL13A Ribosomal protein L13a $495.00 |
A ready-to-use Mouse Gdnf Signaling PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against GDNF signaling genes and 8 housekeeping gene primer sets. Provided in a 96-well microplate (20 ul - 10 uM) Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction) Just add cDNA template and SYBR green master mix GENE LIST: Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Akt1 v-akt murine thymoma viral oncogene homolog 1 Akt2 v-akt murine thymoma viral oncogene homolog 2 Akt3 v-akt murine thymoma viral oncogene homolog 3 Artn artemin Bad BCL2-associated agonist of cell death Bax BCL2-associated X protein Bcl2 B-cell CLL/lymphoma 2 Cdc25A cell division cycle 25A Cdk2 cyclin-dependent kinase 2 Cdkn1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) Creb1 cAMP responsive element binding protein 1 Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) Dok1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) Flt1 fms-related tyrosine kinase 1 Fos FBJ murine osteosarcoma viral oncogene homolog Frs2 fibroblast growth factor receptor substrate 2 Fyn FYN proto-oncogene, Src family tyrosine kinase Gab1 GRB2-associated binding protein 1 Gab2 GRB2-associated binding protein 2 Gas1 growth arrest-specific 1 Gdnf glial cell derived neurotrophic factor Gfra1 GDNF family receptor alpha 1 Gfra2 GDNF family receptor alpha 2 Gfra3 GDNF family receptor alpha 3 Gfra4 GDNF family receptor alpha 4 Grb2 growth factor receptor-bound protein 2 Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Hes1 hes family bHLH transcription factor 1 Hey1 hes-related family bHLH transcription factor with YRPW motif 1 Hif1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Hras Harvey rat sarcoma viral oncogene homolog Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Ikbke inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon Ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Il1B interleukin 1, beta Il6 interleukin 6 Il8 interleukin 8 Irs1 insulin receptor substrate 1 Irs2 insulin receptor substrate 2 Itgb1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Itgb3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Jag1 Jagged 1 Jak1 Janus kinase 1 Jak2 Janus kinase 2 Jak3 Janus kinase 3 Jun jun proto-oncogene Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Map2K1 mitogen-activated protein kinase kinase 1 Map2K2 mitogen-activated protein kinase kinase 2 Map2K7 mitogen-activated protein kinase kinase 7 Map3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Mapk1 mitogen-activated protein kinase 1 Mapk10 mitogen-activated protein kinase 10 Mapk3 mitogen-activated protein kinase 3 Mapk8 mitogen-activated protein kinase 8 Mapk9 mitogen-activated protein kinase 9 Met MET proto-oncogene, receptor tyrosine kinase Mmp2 matrix metallopeptidase 2 Mmp7 matrix metallopeptidase 7 Mmp9 matrix metallopeptidase 9 Myc V-Myc Myelocytomatosis Viral Oncogene Homolog Ncam1 neural cell adhesion molecule 1 Nck1 NCK adaptor protein 1 Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Notch1 notch 1 Nrtn neurturin Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 Pdlim7 PDZ and LIM domain 7 (enigma) Plcg1 phospholipase C, gamma 1 Prkca protein kinase C, alpha Prom1 prominin 1 Pspn persephin Pten phosphatase and tensin homolog Ptk2 protein tyrosine kinase 2 Raf1 Raf-1 proto-oncogene, serine/threonine kinase Ret ret proto-oncogene Rps6Ka1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 Rps6Ka2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 Shc1 SHC (Src homology 2 domain containing) transforming protein 1 Sos1 son of sevenless homolog 1 (Drosophila) Src SRC proto-oncogene, non-receptor tyrosine kinase Tert telomerase reverse transcriptase Tff1 trefoil factor 1 Tnf tumor necrosis factor Tp53 tumor protein p53 Twist1 twist family bHLH transcription factor 1 Vegfa vascular endothelial growth factor A Actb Actin, beta B2M Beta-2-microglobulin Gapdh Glyceraldehyde-3-phosphate dehydrogenase Gusb Glucuronidase, beta Hprt1 Hypoxanthine phosphoribosyltransferase 1 Pgk1 Phosphoglycerate kinase 1 Ppia Peptidylprolyl isomerase A Rpl13A Ribosomal protein L13a $495.00 |
A ready-to-use Rat Gdnf Signaling PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against GDNF signaling genes and 8 housekeeping gene primer sets. Provided in a 96-well microplate (20 ul - 10 uM) Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction) Just add cDNA template and SYBR green master mix GENE LIST: Abcg2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Akt1 v-akt murine thymoma viral oncogene homolog 1 Akt2 v-akt murine thymoma viral oncogene homolog 2 Akt3 v-akt murine thymoma viral oncogene homolog 3 Artn artemin Bad BCL2-associated agonist of cell death Bax BCL2-associated X protein Bcl2 B-cell CLL/lymphoma 2 Cdc25A cell division cycle 25A Cdk2 cyclin-dependent kinase 2 Cdkn1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) Creb1 cAMP responsive element binding protein 1 Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) Dok1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) Flt1 fms-related tyrosine kinase 1 Fos FBJ murine osteosarcoma viral oncogene homolog Frs2 fibroblast growth factor receptor substrate 2 Fyn FYN proto-oncogene, Src family tyrosine kinase Gab1 GRB2-associated binding protein 1 Gab2 GRB2-associated binding protein 2 Gas1 growth arrest-specific 1 Gdnf glial cell derived neurotrophic factor Gfra1 GDNF family receptor alpha 1 Gfra2 GDNF family receptor alpha 2 Gfra3 GDNF family receptor alpha 3 Gfra4 GDNF family receptor alpha 4 Grb2 growth factor receptor-bound protein 2 Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Hes1 hes family bHLH transcription factor 1 Hey1 hes-related family bHLH transcription factor with YRPW motif 1 Hif1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Hras Harvey rat sarcoma viral oncogene homolog Ikbkb inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Ikbke inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon Ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Il1B interleukin 1, beta Il6 interleukin 6 Il8 interleukin 8 Irs1 insulin receptor substrate 1 Irs2 insulin receptor substrate 2 Itgb1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Itgb3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Jag1 Jagged 1 Jak1 Janus kinase 1 Jak2 Janus kinase 2 Jak3 Janus kinase 3 Jun jun proto-oncogene Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Map2K1 mitogen-activated protein kinase kinase 1 Map2K2 mitogen-activated protein kinase kinase 2 Map2K7 mitogen-activated protein kinase kinase 7 Map3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase Mapk1 mitogen-activated protein kinase 1 Mapk10 mitogen-activated protein kinase 10 Mapk3 mitogen-activated protein kinase 3 Mapk8 mitogen-activated protein kinase 8 Mapk9 mitogen-activated protein kinase 9 Met MET proto-oncogene, receptor tyrosine kinase Mmp2 matrix metallopeptidase 2 Mmp7 matrix metallopeptidase 7 Mmp9 matrix metallopeptidase 9 Myc V-Myc Myelocytomatosis Viral Oncogene Homolog Ncam1 neural cell adhesion molecule 1 Nck1 NCK adaptor protein 1 Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Notch1 notch 1 Nrtn neurturin Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 Pdlim7 PDZ and LIM domain 7 (enigma) Plcg1 phospholipase C, gamma 1 Prkca protein kinase C, alpha Prom1 prominin 1 Pspn persephin Pten phosphatase and tensin homolog Ptk2 protein tyrosine kinase 2 Raf1 Raf-1 proto-oncogene, serine/threonine kinase Ret ret proto-oncogene Rps6Ka1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 Rps6Ka2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 Shc1 SHC (Src homology 2 domain containing) transforming protein 1 Sos1 son of sevenless homolog 1 (Drosophila) Src SRC proto-oncogene, non-receptor tyrosine kinase Tert telomerase reverse transcriptase Tff1 trefoil factor 1 Tnf tumor necrosis factor Tp53 tumor protein p53 Twist1 twist family bHLH transcription factor 1 Vegfa vascular endothelial growth factor A Actb Actin, beta B2M Beta-2-microglobulin Gapdh Glyceraldehyde-3-phosphate dehydrogenase Gusb Glucuronidase, beta Hprt1 Hypoxanthine phosphoribosyltransferase 1 Pgk1 Phosphoglycerate kinase 1 Ppia Peptidylprolyl isomerase A Rpl13A Ribosomal protein L13a $595.00 |