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Alzheimer's Disease

Alzheimer's disease represents the most common form of dimentia in older people. Research in Alzheimer's disease is focused on identifying the genes that are involved in susceptibility as well as markers that may be useful for diagnosis and treatment. The hallmark feature of Alzheimer's is the association of amyloid plaques in the brain tissue of patients, thus the focus of resarch has been to understand the molecular pathways associated with amyloid biology to better understand the pathology of this disease. Aß and hyperphosphorylated tau affect neurotransmission, axonal transport, signaling cascades, organelle function, and immune response in ways that lead to synaptic loss. In addition to the genes associated with APP processing, downstream pathways including apoptosis, mitochondria, calcium signaling and cell cycle related molecules that may be implicated in the biology of Alzheimer's disease. These genes are contained in the Alzheimer's PCR primer library along with genes that have been identified as candidates for mutation as well as genes that have been identified as biomarkers of Alzheimer's disease.

Human Alzheimer's Disease Primer Library
A ready-to-use Human Alzheimer's Disease PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against Alzheimer's related genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



Gene List:

ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7

ADAM10 ADAM metallopeptidase domain 10

ADAM17 ADAM metallopeptidase domain 17

APAF1 apoptotic peptidase activating factor 1

APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

APH1A APH1A gamma secretase subunit

APOE apolipoprotein E

APP amyloid beta (A4) precursor protein

ATF6 activating transcription factor 6

BACE1 beta-site APP-cleaving enzyme 1

BAD BCL2-associated agonist of cell death

BID BH3 interacting domain death agonist

BIN1 bridging integrator 1

CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit

CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit

CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit

CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit

CALM1 calmodulin 1 (phosphorylase kinase, delta)

CALM2 calmodulin 2 (phosphorylase kinase, delta)

CALM3 calmodulin 3 (phosphorylase kinase, delta)

CALML3 calmodulin-like 3

CALML5 calmodulin-like 5

CAPN1 calpain 1, (mu/I) large subunit

CAPN2 calpain 2, (m/II) large subunit

CASP12 caspase 12

CASP3 caspase 3, apoptosis-related cysteine peptidase

CASP8 caspase 8, apoptosis-related cysteine peptidase

CASP9 caspase 9, apoptosis-related cysteine peptidase

CCL2 chemokine (C-C motif) ligand 2

CD2AP CD2-associated protein

CD33 CD33 molecule

CDK5 cyclin-dependent kinase 5

CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CHP1 calcineurin-like EF-hand protein 1

CHP2 calcineurin-like EF-hand protein 2

CLU clusterin

CR1 complement component (3b/4b) receptor 1 (Knops blood group)

EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3

ENO2 enolase 2 (gamma, neuronal)

EPHA1 EPH receptor A1

ERN1 endoplasmic reticulum to nucleus signaling 1

FABP1 Fatty acid binding protein 1, liver

FADD Fas (TNFRSF6)-associated via death domain

FAS Fas cell surface death receptor

GFAP glial fibrillary acidic protein

GNAQ guanine nucleotide binding protein (G protein), q polypeptide

GRIN1 glutamate receptor, ionotropic, N-methyl D- aspartate 1

GRIN2A glutamate receptor, ionotropic, N-methyl D- aspartate 2A

GRIN2B glutamate receptor, ionotropic, N-methyl D- aspartate 2B

GRIN2C glutamate receptor, ionotropic, N-methyl D- aspartate 2C

GRIN2D glutamate receptor, ionotropic, N-methyl D- aspartate 2D

GSK3B glycogen synthase kinase 3 beta

HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10

IDE insulin-degrading enzyme

IL1B interleukin 1, beta

ITPR1 inositol 1,4,5-trisphosphate receptor, type 1

ITPR2 inositol 1,4,5-trisphosphate receptor, type 2

ITPR3 inositol 1,4,5-trisphosphate receptor, type 3

LPL lipoprotein lipase

LRP1 low density lipoprotein receptor-related protein 1

MAPK1 mitogen-activated protein kinase 1

MAPK3 mitogen-activated protein kinase 3

MAPT Microtubule-associated protein慯au

MME membrane metallo-endopeptidase

MS4A6A membrane-spanning 4-domains, subfamily A, member 6A

NAE1 NEDD8 activating enzyme E1 subunit 1

NCSTN nicastrin

NEFL neurofilament, light polypeptide

NOS1 nitric oxide synthase 1 (neuronal)

NRGN neurogranin (protein kinase C substrate, RC3)

PICALM phosphatidylinositol binding clathrin assembly protein

PLCB1 phospholipase C, beta 1 (phosphoinositide- specific)

PLCB2 phospholipase C, beta 2

PLCB3 phospholipase C, beta 3 (phosphatidylinositol- specific)

PLCB4 phospholipase C, beta 4

PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme

PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme

PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme

PPP3R1 protein phosphatase 3, regulatory subunit B, alpha

PPP3R2 protein phosphatase 3, regulatory subunit B, beta

PSEN1 presenilin 1

PSEN2 presenilin 2

PSENEN presenilin enhancer gamma secretase subunit

RYR3 ryanodine receptor 3

SNCA synuclein, alpha (non A4 component of amyloid precursor)

TNFRSF1A tumor necrosis factor receptor superfamily, member 1A

TREM2 triggering receptor expressed on myeloid cells 2

VSNL1 visinin-like 1

ACTB Actin, beta

B2M Beta-2-microglobulin

GAPDH Glyceraldehyde-3-phosphate dehydrogenase

GUSB Glucuronidase, beta

HPRT1 Hypoxanthine phosphoribosyltransferase 1

PGK1 Phosphoglycerate kinase 1

PPIA Peptidylprolyl isomerase A

RPL13A Ribosomal protein L13a
$495.00
HAZD-I
Mouse Alzheimer's Disease Primer Library
A ready-to-use Mouse Alzheimer's Disease PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against Alzheimer's related genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



Gene List:

ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7

ADAM10 ADAM metallopeptidase domain 10

ADAM17 ADAM metallopeptidase domain 17

APAF1 apoptotic peptidase activating factor 1

APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

APH1A APH1A gamma secretase subunit

APOE apolipoprotein E

APP amyloid beta (A4) precursor protein

ATF6 activating transcription factor 6

BACE1 beta-site APP-cleaving enzyme 1

BAD BCL2-associated agonist of cell death

BID BH3 interacting domain death agonist

BIN1 bridging integrator 1

CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit

CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit

CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit

CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit

CALM1 calmodulin 1 (phosphorylase kinase, delta)

CALM2 calmodulin 2 (phosphorylase kinase, delta)

CALM3 calmodulin 3 (phosphorylase kinase, delta)

CALML3 calmodulin-like 3

CALML5 calmodulin-like 5

CAPN1 calpain 1, (mu/I) large subunit

CAPN2 calpain 2, (m/II) large subunit

CASP12 caspase 12

CASP3 caspase 3, apoptosis-related cysteine peptidase

CASP8 caspase 8, apoptosis-related cysteine peptidase

CASP9 caspase 9, apoptosis-related cysteine peptidase

CCL2 chemokine (C-C motif) ligand 2

CD2AP CD2-associated protein

CD33 CD33 molecule

CDK5 cyclin-dependent kinase 5

CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CHP1 calcineurin-like EF-hand protein 1

CHP2 calcineurin-like EF-hand protein 2

CLU clusterin

CR1 complement component (3b/4b) receptor 1 (Knops blood group)

EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3

ENO2 enolase 2 (gamma, neuronal)

EPHA1 EPH receptor A1

ERN1 endoplasmic reticulum to nucleus signaling 1

FABP1 Fatty acid binding protein 1, liver

FADD Fas (TNFRSF6)-associated via death domain

FAS Fas cell surface death receptor

GFAP glial fibrillary acidic protein

GNAQ guanine nucleotide binding protein (G protein), q polypeptide

GRIN1 glutamate receptor, ionotropic, N-methyl D- aspartate 1

GRIN2A glutamate receptor, ionotropic, N-methyl D- aspartate 2A

GRIN2B glutamate receptor, ionotropic, N-methyl D- aspartate 2B

GRIN2C glutamate receptor, ionotropic, N-methyl D- aspartate 2C

GRIN2D glutamate receptor, ionotropic, N-methyl D- aspartate 2D

GSK3B glycogen synthase kinase 3 beta

HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10

IDE insulin-degrading enzyme

IL1B interleukin 1, beta

ITPR1 inositol 1,4,5-trisphosphate receptor, type 1

ITPR2 inositol 1,4,5-trisphosphate receptor, type 2

ITPR3 inositol 1,4,5-trisphosphate receptor, type 3

LPL lipoprotein lipase

LRP1 low density lipoprotein receptor-related protein 1

MAPK1 mitogen-activated protein kinase 1

MAPK3 mitogen-activated protein kinase 3

MAPT Microtubule-associated protein慯au

MME membrane metallo-endopeptidase

MS4A6A membrane-spanning 4-domains, subfamily A, member 6A

NAE1 NEDD8 activating enzyme E1 subunit 1

NCSTN nicastrin

NEFL neurofilament, light polypeptide

NOS1 nitric oxide synthase 1 (neuronal)

NRGN neurogranin (protein kinase C substrate, RC3)

PICALM phosphatidylinositol binding clathrin assembly protein

PLCB1 phospholipase C, beta 1 (phosphoinositide- specific)

PLCB2 phospholipase C, beta 2

PLCB3 phospholipase C, beta 3 (phosphatidylinositol- specific)

PLCB4 phospholipase C, beta 4

PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme

PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme

PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme

PPP3R1 protein phosphatase 3, regulatory subunit B, alpha

PPP3R2 protein phosphatase 3, regulatory subunit B, beta

PSEN1 presenilin 1

PSEN2 presenilin 2

PSENEN presenilin enhancer gamma secretase subunit

RYR3 ryanodine receptor 3

SNCA synuclein, alpha (non A4 component of amyloid precursor)

TNFRSF1A tumor necrosis factor receptor superfamily, member 1A

TREM2 triggering receptor expressed on myeloid cells 2

VSNL1 visinin-like 1

ACTB Actin, beta

B2M Beta-2-microglobulin

GAPDH Glyceraldehyde-3-phosphate dehydrogenase

GUSB Glucuronidase, beta

HPRT1 Hypoxanthine phosphoribosyltransferase 1

PGK1 Phosphoglycerate kinase 1

PPIA Peptidylprolyl isomerase A

RPL13A Ribosomal protein L13a
$495.00
MAZD-I