Lung cancer is the leading cause of cancer death.
The two main types of lung cancer, non-small cell lung cancer (NSCLC) (approx. 80%) and small cell lung cancer (SCLC) (approx. 20%) exhibit differing histological, clinical and neuroendocrine characteristics.
Lung cancer carcinogenesis is a multi-step process involving genetic and epigenetic alterations resulting in the transformation of normal lung epithelial cells.
A number of mutations have been identified in putative oncogenes including EGFR and KRAS and these have led to the design and implementation of new targeted therapies for lung cancer. In addition, genomic analyses have identified aberrant signaling pathways and biomarkers that may be useful for improving lung cancer diagnosis, prognosis and patient selection for therapy. The Lung Cancer PCR Primer Library consists of a collection of primer sets to amplify key biomarkers and signaling pathway genes that are associated with lung cancer carcinogenesis.