Liver cancer is a leading cause of cancer deaths worldwide afflicting approximately 700,000 people annually.
There are several types of primay liver cancer with hepatocellular carcinoma being the most common, often developing from cirrhosis.
Hepatocellular carcinomas exhibit substantial heterogeneity, which compounds the difficulties in developing effective therapies against this highly lethal cancer.
The major oncogenic pathways involved in hepatocellular carcinoma are PI3K-Akt, myc, Wnt/β-catenin, c-Met, and hedgehog signaling pathways.
Despite some advances in this field, the molecular pathology of hepatocellular carcinoma remains an active area of investigation.
The Liver Cancer Primer Library contains primer sets for PCR arrays that amplify genes associated with liver cancer carcinogenesis and progression.