KINOME

Protein kinases catalyze the transfer of high energy phosphate groups to variety of substrates including peptide/proteins, lipids, carbohydrates and nucleic acids. This conversion generally results in a significant change in conformation or activity of the receptor molecule. A number of processes may be affected including cell motility, transcription, signaling and transport. Cell biology and the underlying pathology of many diseases may be linked to the inherent activity or expression of protein kinases. Thus quantitation of the amount or activity of each kinase has the potential to yield information regarding the pathways underlying a particular phenotype. The human kinase library contains primer sets for over 350 kinases and offers the opportunity to use quantitative real time PCR arrays to identify changes in kinase gene expression.

A ready-to-use Human Kinase I PCR primer library that may be used to set up to 100 PCR arrays. Contains 96 primer sets directed against human kinase genes.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

ABL1 c-abl oncogene 1, non-receptor tyrosine kinase

ACVR1 activin A receptor, type I

ACVR1B activin A receptor, type IB

ACVR1C activin A receptor, type IC

ACVR2A activin A receptor, type IIA

ACVR2B activin A receptor, type IIB

ACVRL1 activin A receptor type II-like 1

ADRBK1 adrenergic, beta, receptor kinase 1

ADRBK2 adrenergic, beta, receptor kinase 2

AKAP13 A kinase (PRKA) anchor protein 13

AKAP8 A kinase (PRKA) anchor protein 8

AKT1 v-akt murine thymoma viral oncogene homolog 1

AKT2 v-akt murine thymoma viral oncogene homolog 2

AKT3 v-akt murine thymoma viral oncogene homolog 3

ALDH18A1 aldehyde dehydrogenase 18 family, member A1

ALK anaplastic lymphoma receptor tyrosine kinase

AMHR2 anti-Mullerian hormone receptor, type II

ARAF v-raf murine sarcoma 3611 viral oncogene homolog

ATM ataxia telangiectasia mutated

ATR ataxia telangiectasia and Rad3 related

AURKA aurora kinase A

AXL AXL receptor tyrosine kinase

BLK B lymphoid tyrosine kinase

BMPR1A bone morphogenetic protein receptor, type IA

BMPR1B bone morphogenetic protein receptor, type IB

BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)

BMX BMX non-receptor tyrosine kinase

BRAF v-raf murine sarcoma viral oncogene homolog B1

BRD2 bromodomain containing 2

BRD3 bromodomain containing 3

BRD4 bromodomain containing 4

BRDT bromodomain, testis-specific

BTK Bruton agammaglobulinemia tyrosine kinase

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)

CALM1 calmodulin 1 (phosphorylase kinase, delta)

CAMK1D calcium/calmodulin-dependent protein kinase ID

CAMK1G calcium/calmodulin-dependent protein kinase IG

CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1

CAMK4 calcium/calmodulin-dependent protein kinase IV

CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha

CCL2 chemokine (C-C motif) ligand 2

CCNH cyclin H

CDK1 cyclin-dependent kinase 1

CDK12 cyclin-dependent kinase 12

CDK16 cyclin-dependent kinase 16

CDK2 cyclin-dependent kinase 2

CDK3 cyclin-dependent kinase 3

CDK4 cyclin-dependent kinase 4

CDK5 cyclin-dependent kinase 5

CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)

CDK6 cyclin-dependent kinase 6

CDK7 cyclin-dependent kinase 7

CDK8 cyclin-dependent kinase 8

CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)

CDKN2A cyclin-dependent kinase inhibitor 2A

CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

CDKN3 cyclin-dependent kinase inhibitor 3

CERK ceramide kinase

CHEK1 checkpoint kinase 1

CHUK conserved helix-loop-helix ubiquitous kinase

CKM creatine kinase, muscle

CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)

CKS1B CDC28 protein kinase regulatory subunit 1B

CKS2 CDC28 protein kinase regulatory subunit 2

COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

CSF1R colony stimulating factor 1 receptor

CSK c-src tyrosine kinase

CSNK1A1 casein kinase 1, alpha 1

CSNK1D casein kinase 1, delta

CSNK1E casein kinase 1, epsilon

CSNK2A2 casein kinase 2, alpha prime polypeptide

CSNK2B casein kinase 2, beta polypeptide

DAPK1 death-associated protein kinase 1

DAPK2 death-associated protein kinase 2

DCAKD dephospho-CoA kinase domain containing

DCLK1 doublecortin-like kinase 1

DDR1 discoidin domain receptor tyrosine kinase 1

DDR2 discoidin domain receptor tyrosine kinase 2

DGKA diacylglycerol kinase, alpha 80kDa

DGKB diacylglycerol kinase, beta 90kDa

DGKD diacylglycerol kinase, delta 130kDa

DGKE diacylglycerol kinase, epsilon 64kDa

DGKG diacylglycerol kinase, gamma 90kDa

DGKH diacylglycerol kinase, eta

DGKI diacylglycerol kinase, iota

DGKK diacylglycerol kinase, kappa

DGKQ diacylglycerol kinase, theta 110kDa

DGKZ diacylglycerol kinase, zeta

DLG1 discs, large homolog 1

DLG2 discs, large homolog 2

DOK4 docking protein 4

DTYMK deoxythymidylate kinase (thymidylate kinase)

EFNA1 ephrin-A1

$395.00
HKIN-I
A ready-to-use Human Kinase II PCR primer library that may be used to set up to 100 PCR arrays. Contains 96 primer sets directed against human kinase genes.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

EFNA2 ephrin-A2

EFNA3 ephrin-A3

EFNA4 ephrin-A4

EFNA5 ephrin-A5

EFNB1 ephrin-B1

EFNB2 ephrin-B2

EFNB3 ephrin-B3

EGFR epidermal growth factor receptor

EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1

EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2

EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3

EPHA3 EPH receptor A3

EPHA4 EPH receptor A4

EPHA5 EPH receptor A5

EPHA8 EPH receptor A8

EPHB3 EPH receptor B3

EPHB4 EPH receptor B4

ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4

ERN1 endoplasmic reticulum to nucleus signaling 1

FER fer (fps/fes related) tyrosine kinase

FES feline sarcoma oncogene

FGFR1 fibroblast growth factor receptor 1

FGFR2 fibroblast growth factor receptor 2

FGFR4 fibroblast growth factor receptor 4

FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

FKBP1A FK506 binding protein 1A, 12kDa

FLT1 fms-related tyrosine kinase 1

FLT3 fms-related tyrosine kinase 3

FLT4 fms-related tyrosine kinase 4

FRK fyn-related kinase

FYN FYN oncogene related to SRC, FGR, YES

GCK glucokinase (hexokinase 4)

GEM GTP binding protein overexpressed in skeletal muscle

GIT1 G protein-coupled receptor kinase interacting ArfGAP 1

GIT2 G protein-coupled receptor kinase interacting ArfGAP 2

GRK6 G protein-coupled receptor kinase 6

GSK3A glycogen synthase kinase 3 alpha

GSK3B glycogen synthase kinase 3 beta

GTF2I general transcription factor IIi

GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor)

GUCY2F guanylate cyclase 2F, retinal

HCK hemopoietic cell kinase

HIPK2 homeodomain interacting protein kinase 2

HK1 hexokinase 1

HK2 hexokinase 2

HK3 hexokinase 3

HSPB8 heat shock 22kDa protein 8

HUNK hormonally up-regulated Neu-associated kinase

ICK intestinal cell (MAK-like) kinase

IGF1R insulin-like growth factor 1 receptor

IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

ILK integrin-linked kinase

INPP5K inositol polyphosphate-5-phosphatase K

INSR insulin receptor

INSRR insulin receptor-related receptor

IRAK1 interleukin-1 receptor-associated kinase 1

IRAK2 interleukin-1 receptor-associated kinase 2

IRAK4 interleukin-1 receptor-associated kinase 4

ITK IL2-inducible T-cell kinase

ITPKA inositol-trisphosphate 3-kinase A

ITPKC inositol-trisphosphate 3-kinase C

JAK1 Janus kinase 1

JAK2 Janus kinase 2

JAK3 Janus kinase 3

KDR kinase insert domain receptor (a type III receptor tyrosine kinase)

KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

LATS1 LATS, large tumor suppressor, homolog 1

LATS2 LATS, large tumor suppressor, homolog 2

LCK lymphocyte-specific protein tyrosine kinase

LIMK1 LIM domain kinase 1

LIMK2 LIM domain kinase 2

LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

MADD MAP-kinase activating death domain

MAP2K1 mitogen-activated protein kinase kinase 1

MAP2K2 mitogen-activated protein kinase kinase 2

MAP2K3 mitogen-activated protein kinase kinase 3

MAP2K4 mitogen-activated protein kinase kinase 4

MAP2K5 mitogen-activated protein kinase kinase 5

MAP2K6 mitogen-activated protein kinase kinase 6

MAP2K7 mitogen-activated protein kinase kinase 7

MAP3K10 mitogen-activated protein kinase kinase kinase 10

MAP3K14 mitogen-activated protein kinase kinase kinase 14

MAP3K2 mitogen-activated protein kinase kinase kinase 2

MAP3K3 mitogen-activated protein kinase kinase kinase 3

MAP3K4 mitogen-activated protein kinase kinase kinase 4

MAP3K5 mitogen-activated protein kinase kinase kinase 5

MAP3K7 mitogen-activated protein kinase kinase kinase 7

MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4

MAPK1 mitogen-activated protein kinase 1

MAPK10 mitogen-activated protein kinase 10

MAPK11 mitogen-activated protein kinase 11

MAPK12 mitogen-activated protein kinase 12

MAPK13 mitogen-activated protein kinase 13

MAPK14 mitogen-activated protein kinase 14

$395.00
HKIN-II
A ready-to-use Human Kinase III PCR primer library that may be used to set up to 100 PCR arrays. Contains 96 primer sets directed against human kinase genes.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

MAPK3 mitogen-activated protein kinase 3

MAPK6 mitogen-activated protein kinase 6

MAPK7 mitogen-activated protein kinase 7

MAPK8 mitogen-activated protein kinase 8

MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3

MAPK9 mitogen-activated protein kinase 9

MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2

MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5

MARCKS myristoylated alanine-rich protein kinase C substrate

MARK1 MAP/microtubule affinity-regulating kinase 1

MELK maternal embryonic leucine zipper kinase

MERTK c-mer proto-oncogene tyrosine kinase

MET met proto-oncogene (hepatocyte growth factor receptor)

MKNK1 MAP kinase interacting serine/threonine kinase 1

MOS v-mos Moloney murine sarcoma viral oncogene homolog

MSN moesin

MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

MTOR mechanistic target of rapamycin (serine/threonine kinase)

MYO3B myosin IIIB

NCK2 NCK adaptor protein 2

NDRG1 N-myc downstream regulated 1

NEK11 NIMA (never in mitosis gene a)- related kinase 11

NEK2 NIMA (never in mitosis gene a)-related kinase 2

NEK4 NIMA (never in mitosis gene a)-related kinase 4

NEK7 NIMA (never in mitosis gene a)-related kinase 7

NEK8 NIMA (never in mitosis gene a)-related kinase 8

NIN ninein (GSK3B interacting protein)

NLK nemo-like kinase

NME1 NME/NM23 nucleoside diphosphate kinase 1

NME4 NME/NM23 nucleoside diphosphate kinase 4

NME5 NME/NM23 family member 5

NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

NRBP2 nuclear receptor binding protein 2

NTRK1 neurotrophic tyrosine kinase, receptor, type 1

NTRK2 neurotrophic tyrosine kinase, receptor, type 2

NTRK3 neurotrophic tyrosine kinase, receptor, type 3

NUAK1 NUAK family, SNF1-like kinase, 1

OLIG2 oligodendrocyte lineage transcription factor 2

OSR1 odd-skipped related 1

PACSIN2 protein kinase C and casein kinase substrate in neurons 2

PAK3 p21 protein (Cdc42/Rac)-activated kinase 3

PAK6 p21 protein (Cdc42/Rac)-activated kinase 6

PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)

PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)

PDGFRA platelet-derived growth factor receptor, alpha polypeptide

PDGFRB platelet-derived growth factor receptor, beta polypeptide

PDK1 pyruvate dehydrogenase kinase, isozyme 1

PDK2 pyruvate dehydrogenase kinase, isozyme 2

PDK3 pyruvate dehydrogenase kinase, isozyme 3

PDK4 pyruvate dehydrogenase kinase, isozyme 4

PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

PFKL phosphofructokinase, liver

PFKM phosphofructokinase, muscle

PFKP phosphofructokinase, platelet

PGK1 phosphoglycerate kinase 1

PGK2 phosphoglycerate kinase 2

PHKA1 phosphorylase kinase, alpha 1 (muscle)

PHKB phosphorylase kinase, beta

PHKG1 phosphorylase kinase, gamma 1 (muscle)

PHKG2 phosphorylase kinase, gamma 2 (testis)

PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide

PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide

PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide

PIK3C3 phosphoinositide-3-kinase, class 3

PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide

PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide

PIK3CD phosphoinositide-3-kinase, catalytic, delta polypeptide

PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide

PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4

PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5

PIM2 pim-2 oncogene

PINK1 PTEN induced putative kinase 1

PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

PKLR pyruvate kinase, liver and RBC

PKMYT1 protein kinase, membrane associated tyrosine/threonine 1

PKN1 protein kinase N1

PKN3 protein kinase N3

PLAU plasminogen activator, urokinase

PLAUR plasminogen activator, urokinase receptor

PLK1 polo-like kinase 1

PLK2 polo-like kinase 2

PLK3 polo-like kinase 3

PMVK phosphomevalonate kinase

PNKP polynucleotide kinase 3'-phosphatase

PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit

PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit

PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit

PRKACB protein kinase, cAMP-dependent, catalytic, beta

PRKAG2 protein kinase, AMP-activated, gamma 2 non- catalytic subunit

PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta

PRKCA protein kinase C, alpha

PRKCB protein kinase C, beta

PRKCD protein kinase C, delta

$395.00
HKIN-III
A ready-to-use Human Kinase IV PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against human kinase genes plus 8 housekeeping genes.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

PRKCE protein kinase C, epsilon

PRKCH protein kinase C, eta

PRKCI protein kinase C, iota

PRKCQ protein kinase C, theta

PRKCZ protein kinase C, zeta

PRKD1 protein kinase D1

PRKD3 protein kinase D3

PRKDC protein kinase, DNA-activated, catalytic polypeptide

PRKG1 protein kinase, cGMP-dependent, type I

PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)

PRPS1 phosphoribosyl pyrophosphate synthetase 1

PRPS2 phosphoribosyl pyrophosphate synthetase 2

PSKH2 protein serine kinase H2

PTK2 PTK2 protein tyrosine kinase 2

PTK2B protein tyrosine kinase 2 beta

PSTK phosphoseryl-tRNA kinase

PTK6 PTK6 protein tyrosine kinase 6

RAF1 v-raf-1 murine leukemia viral oncogene homolog 1

RB1CC1 RB1-inducible coiled-coil 1

RBKS ribokinase

RET ret proto-oncogene

RFK riboflavin kinase

RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1

RIPK2 receptor-interacting serine-threonine kinase 2

RIPK3 receptor-interacting serine-threonine kinase 3

ROCK1 Rho-associated, coiled-coil containing protein kinase 1

ROCK2 Rho-associated, coiled-coil containing protein kinase 2

ROR2 receptor tyrosine kinase-like orphan receptor 2

ROS1 c-ros oncogene 1 , receptor tyrosine kinase

RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1

RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2

RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3

RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4

RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5

RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1

RYK receptor-like tyrosine kinase

SGK1 serum/glucocorticoid regulated kinase 1

SGK3 serum/glucocorticoid regulated kinase family, member 3

SIK1 salt-inducible kinase 1

SIK2 salt-inducible kinase 2

SIK3 SIK family kinase 3

SKAP1 src kinase associated phosphoprotein 1

SKP1 S-phase kinase-associated protein 1

SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

SMG1 smg-1 homolog, phosphatidylinositol 3-kinase- related kinase

SPAG9 sperm associated antigen 9

SPHK1 sphingosine kinase 1

SPHK2 sphingosine kinase 2

SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

SRPK1 SRSF protein kinase 1

STK10 serine/threonine kinase 10

STK11 serine/threonine kinase 11

STK16 serine/threonine kinase 16

STK17B serine/threonine kinase 17b

STK24 serine/threonine kinase 24

STK25 serine/threonine kinase 25

STK3 serine/threonine kinase 36

STK36 serine/threonine kinase 36

STK39 serine threonine kinase 39

SYK spleen tyrosine kinase

TAOK1 TAO kinase 1

TBK1 TANK-binding kinase 1

TEK TEK tyrosine kinase, endothelial

TESK2 testis-specific kinase 2

TGFBR1 transforming growth factor, beta receptor 1

TGFBR2 transforming growth factor, beta receptor II (70/80kDa)

TIE1 tyrosine kinase with immunoglobulin-like and EGF- like domains 1

TLK2 tousled-like kinase 2

TNK2 tyrosine kinase, non-receptor, 2

TRIM24 tripartite motif containing 24

TRIO triple functional domain (PTPRF interacting)

TTBK1 tau tubulin kinase 1

TTBK2 tau tubulin kinase 2

TYK2 tyrosine kinase 2

TYRO3 TYRO3 protein tyrosine kinase

ULK1 Unc-51 like kinase 1

UCK2 uridine-cytidine kinase 2

ULK2 unc-51-like kinase 2

ULK3 unc-51-like kinase 3

ULK4 unc-51-like kinase 4

VRK3 vaccinia related kinase 3

WEE1 WEE1 homolog

WNK2 WNK lysine deficient protein kinase 2

XRCC6BP1 XRCC6 binding protein 1

YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

ZAK sterile alpha motif and leucine zipper containing kinase AZK

ZMYND8 zinc finger, MYND-type containing

ACTB Actin, beta

B2M Beta-2-microglobulin

GAPD Glyceraldehyde-3-phosphate dehydrogenase

GUSB Glucuronidase, beta

HPRT1 Hypoxanthine phosphoribosyltransferase 1

PGK Phosphoglycerate kinase 1

PPIA Peptidylprolyl isomerase A

RPL13A Ribosomal protein L13a

$395.00
HKIN-IV
Contains all Human Kinase Libraries (I, II, III and IV)listed above.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix
$1,395.00
HKIN-X